The purpose of this current study is to determine the level of predicting the psychological flexibility of teachers on their life satisfaction and to evaluate the psychological flexibility of teachers according to their various demographic characteristics. For this purpose, data were collected from 373 teachers working in Bursa in the 2021-2022 academic year. Research data were collected using Demographic Information Form, Psychological Resilience Scale and Life Satisfaction Scale. In the study, the differences in the psychological flexibility of teachers according to gender, marital status and educational status were examined by using the Independent Samples t-Test. Multiple Linear Regression Analysis was used to determine the level to which participants' psychological flexibility levels predicted their life satisfaction. The findings showed that the psychological flexibility total scores of female participants were higher than male participants. There was no significant difference in the psychological flexibility levels of the participants according to their marital status and educational status. The scores of values and committed action, contact with the present moment, self as context and diffusion, which are the sub-dimensions of psychological flexibility, significantly predicted the participants' life satisfaction. These sub-dimensions were found to explain 21% of the change in the participants' life satisfaction. Acceptance sub-dimension of psychological flexibility did not significantly predict life satisfaction.